目的 硫糖铝的胃黏膜保护作用与其在酸性条件下形成不溶性的凝胶有关,但在临床上硫糖铝经常与抑酸药合用,而合用的抑酸药对硫糖铝的疗效及安全性的影响目前还不清楚。方法 通过体外观察硫糖铝混悬液凝胶形成的pH及其性状,了解硫糖铝发挥疗效的适应pH值;以电感耦合等离子发射光谱(ICP-OES)法测定上清液中铝离子浓度,了解硫糖铝的可能不良作用。结果 硫糖铝在pH为0.1时可完全溶解;pH为0.7,1.0和2.0的条件下可形成白色较软、黏附性强、伸展性佳的凝胶,随着放置时间的延长,逐渐形成沉淀;pH≥3.0时无法形成凝胶;pH>4.0时可形成质地较硬、无明显黏附和伸展性的白色沉淀物。在pH 0.1~7.0内,随着pH的升高,游离铝离子的量逐渐降低。结论 硫糖铝联用抑酸药不会增加铝离子的吸收,但是否具有协同作用,值得商榷。
Abstract
OBJECTIVE To investigate the effect of antacids on the efficacy and safety of sucralfate. METHODS The appearance of sucralfate suspension gel was observed under different pHs in vitro to learn the appropriate pH for sucralfate to work. The adverse effects of sucralfate was evaluated by determining the aluminum ion concentration in the supernatant using emission spectrometry with inductively coupled plasma (ICP-OES). RESULTS At pH 0.1, sucralfate was partly dissolved; at pH 1.0 and 2.0, it formed white soft gel with strong adhesion and good extension; along with the storage time, the gel gradually precipitated; at pH≥3, sucralfate was unable to form gel; at pH>4.0, it formed a hard white precipitate without obvious adhesion and spreadability. In the pH range of 0.1-7.0, the concentration of free aluminum ion reduced gradually with the increase of pH. CONCLUSION Combination use of antacids with sucralfate does not increase the aluminum ion absorption, but whether there is a synergistic effec is worth of further exploration.
关键词
硫糖铝 /
凝胶 /
pH /
铝离子
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Key words
sucralfate /
Gel /
pH /
Aluminiumion
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中图分类号：
R944
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参考文献
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脚注
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基金
浙江省教育厅项目(Y200908690)
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